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Revolutionary Advancement in Managing Diabetes: A Promising Medical Breakthrough

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Warren Henry
Warren Henry is a tech geek and video game enthusiast whose engaging and immersive narratives explore the intersection of technology and gaming.

Stem cells from the human stomach can be converted into insulin-secreting cells in response to elevated blood sugar levels, providing a promising approach to treating type 1 diabetes.

In a study published in the journal Nature Cell Biology, scientists have shown that they can take stem cells derived from human stomach tissue and directly reprogram them with surprisingly high efficiency into cells very similar to insulin-secreting pancreatic cells known as beta-cells. cells. .

An experiment conducted by researchers at Weill Cornell Medicine in the US showed that transplantation of insulin-secreting gastric cells (GINS) reversed the signs of diabetes in mice.

Pancreatic beta cells normally release the hormone insulin in response to high blood sugar levels.

In people with diabetes, these tissues become damaged or die, which affects their ability to transport glucose into cells for energy.

Although GINS are not beta cells, they can mimic their function.

The gut contains many stem cells that can transform into many other cell types and multiply rapidly.

It is hoped that diabetics will be able to convert their own stem cells into gastric insulin-secreting cells (GINS), which will reduce the risk of rejection.

“The stomach produces its own hormone-secreting cells, and stomach cells and pancreatic cells coexist in the embryonic stage of development, so it is not surprising that stomach stem cells are easily transformed into hormone-secreting cells,” says Jo Zhu, MD, associate professor. regenerative medicine at Weill Cornell Medicine in New York beta-like insulin.

Scientists have been trying to get something like this to work for years, with little success. In this recent study, the team activated three specific proteins in cells that control gene expression in a specific order to induce a switch to gastric insulin secretion (GINS).

The reprogramming process is very efficient, and when the cells were grown in small groups known as organelles, they showed sensitivity to glucose. Then they were able to show long-term effects on diabetes in mice.

The team says that the production of insulin secretion in the stomach from stomach cells is not a complex process and only takes a few days, and these new organelles can persist for several months after transplantation, based on their tests.

In their report, the researchers noted: “Gastric insulin-secreting organelles (GINS) showed a response to glucose after 10 days of stimulation. They were stable after transplantation by monitoring (6 months), human insulin secretion and reversible diabetes in mice.”

The hormone insulin is critical for regulating blood sugar levels. Without adequate levels, we risk various health complications.

Millions of people around the world suffer from diabetes and they often use insulin injections to control their glucose levels.

This method is still very early, but it will allow the body to manage insulin levels normally again.

The researchers noted several differences between human and mouse stomach tissues that need to be addressed in future studies, while insulin-secreting cells in the stomach (GINS) should also be less vulnerable to attacks from the immune system.

However, early signs are encouraging. The findings add to a range of ways scientists are looking to tackle diabetes, including improving diet and adjusting the way insulin is delivered to the body.

Source: Science Alert

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