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Unprecedented Recovery: Three Patients with Fatal Heart Failure Saved by Medical Breakthrough

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Mary McNally
Mary McNally is a UK-based author exploring the intersection of fashion, culture, and communication. With a talent for vivid storytelling, Mary's writing captures the complexities of modern life engagingly and authentically.

According to The New England Journal, a group of heart failure patients spontaneously recovered from the disease in an “unprecedented state.” of Medicine.

Three of the men had heart failure due to cardiac amyloidosis, a buildup of toxic proteins in the heart called amyloids that make it hard for that organ to function properly.

The chronic disease worsens over time and is sometimes fatal, leading experts to characterize it as an irreversible condition.

Scientists from University College London (UCL) and the Royal Free Hospital conducted physical examinations of men aged 68, 76 and 82 after reports of an improvement in their symptoms.

Tests showed that some of the toxic proteins had disappeared from their hearts, which seemed to be recovering from the disease.

The team also found promising evidence for antibodies that specifically target these proteins.

Further studies showed that in other patients, whose condition developed normally, these antibodies were not detected.

Medical professionals hope the findings will lead to new treatments for the disease. Lead investigator Prof Mariana Fontana from the Faculty of Medicine, University College London, said: “We have seen for the first time that the heart can improve with this disease. new methods of treatment.

In the study, the researchers looked at a specific type of condition caused by a buildup of a transporter protein called transurethrin (TTR) in the blood.

Transcritin-induced cardiac amyloidosis (also called ATTR amyloidosis or ATTR-CM cardiomyopathy) is little known due to possible underdiagnosis and underreporting.

The team studied the records of 1,663 patients with the disease after one of the men, aged 68, said his symptoms were improving.

Two other cases of improvement were identified and confirmed using blood tests, scans and medical imaging techniques.

The team found antibodies in three patients that specifically bind to ATTR amyloid deposits in human and mouse tissues in the lab.

The scientists said using these antibodies could help remove toxic proteins and possibly reverse the disease.

Scientists led by Professor Julian Gilmour of the University of California, Los Angeles School of Medicine, are looking for a gene editing method that could stop the progression of cardiac amyloidosis.

The team said early test results suggest it could stop the progression of the disease. Professor Gilmour, who is also head of the University College London Amyloidosis Center at the Royal Free Hospital, explained: “It has not been established whether these antibodies cause patients to recover. However, our data suggest that this is very likely and there is potential for recovery. “Such antibodies can be found in the laboratory and used as a treatment. We are currently conducting further research, although this research is still in its early stages.”

Source: Independent

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